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23

April

Research Fellow

Monash University - Clayton, VIC

Education, Childcare & Training
Source: uWorkin

JOB DESCRIPTION

Full Job Description
The Opportunity

An exciting opportunity has become available for a motivated and talented individual to join the Faculty of Medicine, Nursing, and Health Sciences as a Research Fellow in the Davey Laboratory. Part of a broad collaborative project funded by the United States Department of Defense, the role will explore the influence of gamma delta T cells and the gamma delta T cell receptor in Inflammatory bowel disease (IBD). IBD encompasses Crohn’s disease and ulcerative colitis. IBD commonly presents from childhood into early adulthood. In 2017, there were estimated to be 6 - 8 million cases of IBD globally.

One area we lack clarity on is the immune systems dysregulation in IBD. The gastrointestinal tract contains billions of microorganisms living in harmony with the immune system. These microbes are separated from immune cells by a barrier, called the intestinal epithelium. The immune cells that patrol and protect this barrier include specialized cells that express a T cell receptor (TCR) and termed T cells. These T cells are able to respond and react to characteristic molecules the microbes produce, known as antigens. It is thought that an inadvertent TCR-mediated response may trigger a chain of events that result in gastrointestinal inflammation and intestinal damage, at the root of IBD.

In this project, we will study a poorly understood group of T cells that express a particular TCR called a gamma delta TCR. These gamma delta T cells are major population that patrol the intestinal epithelium. We believe the changes in gamma delta T cells is directed by their TCRs. We will explore these concepts using world leading and innovative techniques to look at the gamma delta TCR interactions in extraordinary detail. We will uncover how these TCRs change in healthy patients compared to IBD and understand the details of the surface interactions that drive these responses.

The Davey laboratory seeks to build upon current findings and ongoing research and presents a unique opportunity for a Research Fellow to conduct research independently, and to provide guidance to junior lab members, within the scope of their research expertise.

To be successful in this role you will have;

A PhD in Immunology or Molecular Biology or a related discipline from a recognised university or equivalent qualifications and research experience in the area.
Ability to solve complex problems by using discretion and innovation by exercising diagnostic skills
A strong research track record including published papers in the field of immunology

If you believe you have the skills and experience to undertake this role, we look forward to receiving your application.

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. For instructions on how to apply, please refer to “How to apply for Monash Jobs”.

Enquiries

Dr Martin Davey, ARC DECRA Fellow, and Group leader;

T:+61 03 9905 0255

E: martin.davey@monash.edu

Dr Ben Gully, Research Fellow, and Group leader;

T: +61 03 9905 3169

E: ben.gully@monash.edu

Position Description

Research Fellow

Closing Date

Sunday 9 May 2021, 11:55pm AEST

Supporting a diverse workforce

Clayton, VIC

Education, Childcare & Training




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