3 Easy Steps

  • 1Search for courses by Study Area, Level and Location
  • 2We deliver you all the matched results
  • 3Choose one or more course providers to contact you
Industry

Distance from location (kms)

Exact 5 10 25 50 100

Posted since

All 2 Days 1 Week 2 Weeks 1 Month

Sort results by

Relevance Date

7

February

Research Fellow (Proteostasis)

Monash University - Clayton, VIC

Education, Childcare & Training
Source: uWorkin

JOB DESCRIPTION

Research Fellow (Proteostasis)

Job No.: 609361

Location: Clayton campus

Employment Type: Full-time

Duration: 12-month fixed-term appointment

Remuneration: $69,401 - $94,190 pa Level A (plus 9.5% employer superannuation)

  • Be inspired, every day
  • Drive your own learning at one of the world’s top 80 universities
  • Take your career in exciting, rewarding directions

Everyone needs a platform to launch a satisfying career. At Monash, we give you the space and support to take your career in all kinds of exciting new directions. You’ll have access to quality research, infrastructure and learning facilities, opportunities to collaborate internationally, as well as the grants you’ll need to publish your work. We’re a university full of energetic and enthusiastic minds, driven to challenge what’s expected, expand what we know, and learn from other inspiring, empowering thinkers.

The Opportunity

The Group of Dr Nadinath B. Nillegoda at the Australian Regenerative Medicine Institute, Monash University is seeking a dedicated and passionate Research Fellow interested in studying host chaperones hijacked by RNA viruses including coronaviruses and develop chaperone-based antiviral agents to block RNA viral replication in human cells using interdisciplinary approaches.

The overarching research themes in the Nillegoda laboratory involve proteostasis, cell repair, and protein conformational disorders in humans. Recently, in response to the COVID-19 pandemic, the Group has established a new direction to study the proteostasis of RNA viruses with a multidisciplinary research team including experts in virology and peptide chemistry.

Brief project background: Proteostasis of RNA viruses is maintained by hijacking protein quality control systems that assist in protein folding in the host cell under physiological conditions. The Heat shock protein 70 (Hsp70) chaperone system, which supports a plethora of host proteostasis functions, is a vital chaperone exploited by viruses to facilitate virion biogenesis. Our preliminary findings demonstrate that the host Hsp70 chaperone network could be targeted to develop a broad-spectrum of novel antiviral agents. The work will also investigate the role of protein disaggregases in RNA viral biogenesis.

We are seeking a highly motivated individual with a doctoral qualification or progress towards a doctoral qualification in cellular protein quality control systems, molecular chaperones, and proteostasis. Key requirements also include extensive knowledge in proteostasis, cellular protein quality control pathways, protein folding and molecular chaperones, protein aggregation and cellular stress pathways and/or protein degradation. A strong track record of publications directly linked to proteostasis in peer-reviewed journals is a must. Required techniques/methods include significant experience in molecular cloning/ vector design, mammalian and yeast cell culture, genetic modification of cells (stable cell lines; CRISPR-Cas9 gene editing; designing, handling and generating shRNA clones etc), immunohistochemistry, fluorescence/confocal microscopy and image processing, western blotting, immunoprecipitation, real-time PCR, cell viability assay, radioactive/ cycloheximide pulse-chase assays, and protein purification.

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria.

Enquiries

Dr Nadinath Nillegoda, Group Leader, +61 3 9905 3636

Closing Date

Sunday 7 February 2021, 11:55pm AEDT

Supporting a diverse workforce

For instructions on how to apply, click on the "Apply" button above for the full position description and instructions on how to apply for Monash jobs.

Clayton, VIC

Education, Childcare & Training




APPLY

Shortlist Job